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Mycobacterium tuberculosis (Mtb)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (8) ATP Synthase (1) Bacterial (48) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Isotope-Labeled Compounds (2) Thymidylate Synthase (3)
By Research Areas:	Infection (53) Inflammation/Immunology (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151806

HadAB-IN-1	Bacterial	Infection Inflammation/Immunology
HadAB-IN-1 is a potent HadAB inhibitor. HadAB-IN-1 inhibits HadAB enzyme complexes activity with an IC₅₀ value of 0.03 μM. HadAB-IN-1 also affects mycolic acid biosynthesis in Mycobacterium tuberculosis (Mtb). HadAB-IN-1 can be used for the research of tuberculosis (TB) .

HY-151550

Mtb-cyt-bd oxidase-IN-3	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-3 (compound 1u) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.36 μM. Mtb-cyt-bd oxidase-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC=32 μM). Mtb-cyt-bd oxidase-IN-3 can be used in tuberculosis research .

HY-151551

Mtb-cyt-bd oxidase-IN-4	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-4 (compound 1g) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.25 μM. Mtb-cyt-bd oxidase-IN-4 inhibits the growth of Mycobacterium tuberculosis (MIC=8 μM). Mtb-cyt-bd oxidase-IN-4 can be used in tuberculosis research .

HY-149347

Mtb-IN-3	Bacterial	Infection
Mtb-IN-3 (compound 10c) is an inhibitor of Mycobacterium tuberculosis (Mtb). Mtb-IN-3 shows selective, potent in vitro antimycobacterial activity without cytotoxicity. Mtb-IN-3 inhibits colony-forming in spleen in the murine tuberculosis model .

HY-151549

Mtb-cyt-bd oxidase-IN-2	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-2 is an inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) with an IC₅₀ value of 0.67 μM. Mtb-cyt-bd oxidase-IN-2 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 256 μM. Mtb-cyt-bd oxidase-IN-2 can be used for the research of infection .

HY-145985

CBR-3465

Bacterial Infection

CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .
HY-145986

CBR-6672

Bacterial Infection

CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

CBR-3465	Bacterial	Infection
CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .

CBR-6672	Bacterial	Infection
CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

HY-163181

MSU-43085	Bacterial	Infection
MSU-43085 is an orally active MmpL3 inhibitor of Mycobacterium tuberculosis (Mtb). MSU-43085 effectively inhibits Mtb in an acute murine tuberculosis infection model. MSU-43085 can be used in tuberculosis research .

HY-151548

Mtb-cyt-bd oxidase-IN-1	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-1 (compound 1x) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.13 μM. Mtb-cyt-bd oxidase-IN-1 can be used in tuberculosis research .

HY-155722

Mtb-IN-5	Bacterial	Infection
Mtb-IN-5 (compound (-)17j) is an isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity. Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .

HY-149346

Mtb-IN-2	Bacterial	Infection
Mtb-IN-2 (compound 10c) is an antimicrobial agent against Mycobacterium tuberculosis (Mtb), without cytotoxicity. Mtb-IN-2 significantly decreases colony-forming units (CFU) in spleen of murine tuberculosis models, and distinguishes both drug-sensitive and drug-resistant Mtb H37Rv strains. Mtb-IN-2 affects methionine metabolism but not folate pathway directly.

HY-157870

Mtb-IN-6	Bacterial	Infection
Mtb-IN-6 (Compound C10) is a Mycobacterium tuberculosis(Mtb) respiration inhibitor. Mtb-IN-6 can enhance the bactericidal activity of isoniazid (INH, HY-B0329). Mtb-IN-6 inhibits WT Mtb with an IC₅₀ of 25 µM .

HY-151553

Mtb-cyt-bd oxidase-IN-6	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-6 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC₅₀ value of 0.35 μM. Mtb-cyt-bd oxidase-IN-6 can effectively inhibit the growth of Mtb (MIC= 4 μM). Mtb-cyt-bd oxidase-IN-6 can be used in the study of tuberculosis .

HY-151552

Mtb-cyt-bd oxidase-IN-5	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-5 (compound 1k) is a Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC₅₀ value of 0.37 μM. Mtb-cyt-bd oxidase-IN-5 can effectively inhibit the growth of Mtb (MIC= 256 μM). Mtb-cyt-bd oxidase-IN-5 can be used in the study of tuberculosis .

HY-146388

Mtb ATP synthase-IN-1	Bacterial ATP Synthase	Infection
Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC₅₀ > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium .

HY-148111

Antitubercular agent-33

Bacterial Infection

Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .

Antitubercular agent-33	Bacterial	Infection
Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .

HY-155720

Mtb-IN-4	Bacterial	Infection
Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC₅₀=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .

HY-107775

Ganfeborole hydrochloride 2 Publications Verification GSK656; GSK3036656; GSK070	Bacterial	Infection
Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC₅₀ of 0.2 μM.

HY-139398

TBI-223 1 Publications Verification	Bacterial	Infection
TBI-223 is an orally bioavailable oxazolidinone antibiotic and an antimicrobial. TBI-223 shows activity against Mycobacterium tuberculosis (Mtb) .

HY-146298

Mt KARI-IN-1

Bacterial Infection

Mt KARI-IN-1 (Lead compound) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a K_i value of 3.06 μM .
HY-118281

ATD-3169

Bacterial Infection

ATD-3169 is an antibacterial agent. ATD-3169 enhances endogenous ROS, including superoxide radicals, to inhibit Mycobacterium tuberculosis (Mtb) .

Mt KARI-IN-1	Bacterial	Infection
Mt KARI-IN-1 (Lead compound) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a K_i value of 3.06 μM .

ATD-3169	Bacterial	Infection
ATD-3169 is an antibacterial agent. ATD-3169 enhances endogenous ROS, including superoxide radicals, to inhibit Mycobacterium tuberculosis (Mtb) .

HY-W145657

Trehalose 6,6′-dimycolate Cord Factor	Biochemical Assay Reagents	Infection
Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses .

HY-162328

Antibacterial agent 194	Bacterial	Infection
Antibacterial agent 194 (Compound 19) is an antibacterial agent. Antibacterial agent 194 has potent anti-Mycobacterium tuberculosis (anti-Mtb) activity (MIC = 1 μg/mL) .

HY-115448

Bio-AMS	Bacterial	Infection
Bio-AMS is a potent bacterial biotin protein ligase inhibitor. Bio-AMS possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis .

HY-143249

MtMetAP1-IN-1	Bacterial	Infection
MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting methionine aminopeptidase 1 (MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity .

HY-115448A

Bio-AMS TFA	Bacterial	Infection
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. Bio-AMS (TFA) possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis .

HY-108050

4-Hydroxyoxyphenbutazone	Bacterial	Infection Inflammation/Immunology
4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) **Mycobacterium tuberculosis (Mtb)*, including Mtb* resistant to standard agents. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive agent and has the potential for rheumatoid arthritis research .

HY-150554

Antitubercular agent-29	Bacterial	Infection
Antitubercular agent-29 (compound 6xa) is a potent agent resistant (DR) **Mycobacterium tuberculosis (Mtb) inhibitor with MIC** of 0.03 μg/mL against agent-susceptible (DS)-Mtb strains, MIC of 0.03-0.06 μg/mL against DR-Mtb strains, and favourable selectivity (SI>40) against Vero cells .

HY-154807

DQn-1	Bacterial	Infection
DQn-1 is a potent antifolate with activity against **Mycobacterium tuberculosis (Mtb) (MIC₉₀=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC₅₀*s of 8.7 and 7.6 nM for Mtb* and human DHFR enzyme, respectively .

HY-12904

TCA1	Bacterial	Infection
TCA1 is a small molecule with activity against agent-susceptible and -resistant **Mycobacterium tuberculosis (Mtb)**. TCA1 inhibits enzymes involved in cell wall and molybdenum cofactor biosynthesis, such as DprE1 and MoeW .

HY-14881

Bedaquiline Maximum Cited Publications 31 Publications Verification TMC207; R207910	Bacterial Antibiotic	Infection
Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-153222

SEQ-9	Bacterial	Infection
SEQ-9 is an orally active Mycobacterium tuberculosis (Mtb) 23S bacterial ribosome inhibitor with an IC₅₀ of approximately 170 nM for unmethylated Mtb ribosomes. SEQ-9 also potently inhibits A2296 methylated ribosomes. SEQ-9 can be used to study bacterial infection and drug resistance .

HY-14881B

(Rac)-Bedaquiline (Rac)-TMC207; (Rac)-R207910	Others	Infection
(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-146299

Mt KARI-IN-2	Bacterial	Infection
Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a K_i value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC₅₀ > 86 μg/mL) .

HY-146300

Mt KARI-IN-4	Bacterial	Infection
Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a K_i value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC₅₀ > 72 μg/mL) .

HY-146301

Mt KARI-IN-5	Bacterial	Infection
Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a K_i value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC₅₀ > 64 μg/mL)

HY-152534

MenA-IN-2	Others	Infection
MenA-IN-2 (Compound 11) is an inhibitor of 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA). MenA-IN-2 inhibits MenA with an IC₅₀ value of 22 µM and inhibits Mycobacterium tuberculosis (Mtb) with an GIC₅₀ value of 10 µM. MenA-IN-2 can curb the continuous transmission of Mtb .

HY-14881S2

Bedaquiline impurity 2-d6	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2].

HY-147000

DNA Gyrase-IN-1	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-1 (compound 42) is a potent and selective DNA gyrase inhibitor with an IC₅₀ value of 2.6 µM. DNA Gyrase-IN-1 has high inhibitory activity against Mycobacterium tuberculosis (Mtb) with MIC of 0.49 µM. DNA Gyrase-IN-1 can be used for researching tuberculosis .

HY-152495

MenA-IN-1	Others	Infection
MenA IN-1 is an effective inhibitor of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis (MTB) with an IC₅₀ value of 13 µM and an GIC₅₀ value of 8 µM. MenA IN-1 can be used to curb the continuous spread of tuberculosis .

HY-146447

PXYC13	Bacterial Antibiotic	Infection
PXYC13 is a ribosomal protein S1 (RpsA) antagonist with K_ds of 7.61 and 8.50 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb) .

HY-146450

PXYC2	Bacterial Antibiotic	Infection
PXYC2 is a ribosomal protein S1 (RpsA) antagonist with K_ds of 6.35 and 5.11 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb) .

HY-146449

PXYD4	Bacterial Antibiotic	Infection
PXYD4 is a ribosomal protein S1 (RpsA) antagonist with K_ds of 3.24 and 1.64 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb) .

HY-146446

PXYC1	Bacterial Antibiotic	Infection
PXYC1 is a ribosomal protein S1 (RpsA) antagonist with K_ds of 0.81 and 0.31 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb) .

HY-146448

PXYD3	Bacterial	Infection
PXYD3 is a ribosomal protein S1 (RpsA) antagonist with K_ds of 5.66 and 6.91 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb) .

HY-146451

PXYC12	Bacterial Antibiotic	Infection
PXYC12 is a ribosomal protein S1 (RpsA) antagonist with K_ds of 2.67 and 4.67 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb) .

HY-144663

MtTMPK-IN-1	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-1 (compound 3) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC₅₀ value of 2.5 μM. MtTMPK-IN-1 has moderate to weak activity against Mtb H37Rv and low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 can be used for researching tuberculosis .

HY-14881S1

(Rac)-Bedaquiline-d6	Isotope-Labeled Compounds	Others
(Rac)-Bedaquiline-d₆is the deuterium labeledBedaquiline(HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-125941

PNU-101603	Bacterial	Infection
PNU-101603 is a sulfoxide metabolite of Sutezolid (HY-10392). PNU-101603 alone or combined with SQ109 (HY-14989) shows excellent activity against Mycobacterium tuberculosis (MTB), as well as against agent-susceptible and multidrug-resistant TB .

HY-155059

Antimycobacterial agent-6	Bacterial	Infection
Antimycobacterial agent-6 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis (Mtb)，targeting to both wild-type and fluoroquinolone-resistant Mtb strains. Antimycobacterial agent-6 inhibits Mtb DprE1-C387S mutant with MIC₉₀s of 0.9 μM (H37Rv)，0.9 μM (MoxR)，0.5 μM (DprE1-P116S)，respectively .

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